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(2000) Abnormalities inCSF concentrations of ferritin and transferrin in restless legs syn-drome. Mostoften, the skin changes precede the muscle weakness andinclude a heliotrope rash (blue–purple discoloration) onthe upper eyelids with edema, a fl at red rash on the faceand upper trunk, erythema of the knuckles with a raisedviolaceous scaly eruption (Gottron’s papules), and sub-cutaneous calcium deposits (subcutaneous calcinosis),especially at the elbows.

It is released by mast cells togetherwith histamine and serves as a marker ofmast cell activation.Chymase plays an important role in generating angiotensinII in response tovascular tissue injury. (2006) Long-termeffects of cognitive training on everyday functional outcomes inolder adults.

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Broad-range PCR does not identify detected organisms (unless amplified DNA issequenced) or signal the presence of a polymicrobial infection, and false-positive resultsmay occur from background DNA in clinical specimens or reagents [48].